Maternal and offspring high-fat diet leads to platelet hyperactivation in male mice offspring

Abstract Maternal over-nutrition increases the risk of diabetes and cardiovascular events in offspring. While prominent effects on health are observed, impact platelet physiology has not been studied. Here, we examined whether maternal high-fat diet (HF) ingestion affects function lean obese C57BL6/N mice dams were given a HF or control (C) for 8 weeks before during pregnancy. Male female offspring received C diets 26 weeks. Experimental groups were: C/C, dam fed standard laboratory diet; C/HF HF/C HF/HF. Phenotypic metabolic tests performed blood collected studies. Compared to obese, with fat accumulation, hyperglycaemia insulin resistance. Female did present hyperactivity, hence focused male Platelets from HF/HF larger, hyperactive presented oxidative stress when compared C/C. results hyperactivation mouse offspring, suggesting novel ‘double-hit’ effect.